Monthly Archives: February 2016

Arterial Growth From Optimisation Principles

Arterial Growth From Optimisation Principles
Jonathan J. Keelan, The Open University

(Global metabolic optimality in the structure of the coronary arteries, arXiv:1403.6450, J. Keelan, E.M.L. Chung and J.P. Hague)

Arterial Trees
Approximately Binary (3% Trifurcation)
Delivery and Transport
Topology and Geometry
Energy Requirements
Blood volume maintenance
Pumping power / vascular resistance
Murrays Law
Modelling
Fractal Models
Constrained Constructive Optimisation (CCO)
Morphological Models
Modelling
Blood Supply
Arterial Exclusion
Volume and Power
Simulated Annealing
Geometry
Topology
Boundary Constraints

Results
Results
Bifurcation asymmetry over various metabolic costs
Results
Future Work
Use real tissue geometries (e.g. Brain MRI data)
Model various organs
Incorporate into statistical stroke model

Applications
Medical Imaging Augmentation
Artificial tissue / Organs

Summary
Computational growth of arterial trees
Simulated Annealing algorithm for arbitrary tissue geometries
Accurate reproduction of Morphological / Structural properties

3D Bioprinting Of A Living Aortic Valve

3D Bioprinting of a Living Aortic Valve
Jonathan Butcher (BME)
C.C. Chu (DHE)
Hod Lipson (MAE)
Larry Bonassar (MAE/BME)
Len Girardi (Weill Medical)

Clinical Need and State of the Art
Nearly 100,000 valve replacements annually in US
Prosthetic valves poor choice for young/active
Tissue engineering has potential but limited by inability to mimic 3D anatomy and heterogeneous material properties
Ideal Biomaterial Characteristics for Engineered Heart Valves
Enzymatically bioadsorbable
Cell mediated, non-toxic end products
Aqueous based hydrogel
Can fabricate with cells distributed within matrix
Non-thrombogenic/non-immunogenic
Tunable material properties: crosslinking
Bio-functionality
Charge, hydrophobicity, hydroxyl/amine groups

Arginine Based PEA Hydrogels (A-PEA)
Precursors are water soluble
Can be photo-crosslinked by UV light
Degraded by a variety of cellular enzymes
Numerous accessible functional groups

A-PEA is Minimally Immunogenic/Thrombogenic
3D Hydrogel Cytotoxicity Assay
3D Cyotoxicity with Photo-Crosslinking
Mechanical Testing of Hydrogels
High Throughput Measurement of Photo-Crosslinking Effects
Riboflavin induced crosslinking of collagen I
Central disk punched out via well guide
Dose dependent effects
3D Bioprinting Technology
Next Steps
Switch to A-PEA based hydrogels
Cytotoxicity of crosslinking dose
Mechanical testing of crosslinking effects
Incorporate a second syringe in the printer
Print a temporary scaffold to support structure
Print 3D anatomical models of heart valves
Axisymmetric aortic valve geometry
Anatomical models via MRI: Yi Wang, Weill Med
Incorporate a tuned UV laser to the print head
Spot specific engineered tissue material properties

Coming Attractions- Saving Lives Through 3D Bioprinting

Chapter 8: Strengthening Business-to-Business Relationships via Supply Chain and Customer Relationship Management
Supply chain management (SCM) systems support business-to-business (B2B) transactions; customer relationship management (CRM) systems promote sales and long-term customer relationships
Chapter 8 Learning Objectives
Supply Chain Management
What Is a Supply Chain?
A collection of companies and processes involved in moving a product from the suppliers of raw materials to the suppliers of intermediate components, then to final production, and, ultimately, to the customer
Referred to as a chain as one supplier feeds into the next, then the next, then the next
A network is more accurate because businesses have multiple suppliers, who have multiple suppliers
A Typical Supply Network
Business-to-Business Electronic Commerce: Exchanging Data in Supply Networks
Business-to-Business (B2B) Electronic commerce
90% of all EC in the United States
Involve Proprietary Information
Originally facilitated using Electronic Data Interchange (EDI) prior to the Internet
Now suppliers use Web-based EDI protocols
Companies also use Extranets (Chapter 3), Portals and Marketplaces to facilitate B2B EC
Business-to-Business Electronic Commerce: Exchanging Data in Supply Networks
Portals
Supplier Portals
Customer Portals

B2B Marketplaces
Link many supplies and customers together
Allow smaller businesses to participate in the markets
Many focused on vertical markets
A vertical market is a market within an industry sector
Highly efficient
Some more general îAlibaba.com
Managing Complex Supply Networks
Benefits of Effectively Managing Supply Chains
Just-in-Time Production
Inventory delivered just as it is needed
Minimizes stock and handling costs
Reduces obsolescence charges
Vendor-Managed Inventory
Vendors track usage and replenish supplies
Reduces procurement and inventory replenishment costs
Benefits of Effectively Managing Supply Chains
Reducing the Bullwhip Effect
Ripple effects due to forecast errors
Coordinated supply chain helps mitigate this
Corporate Social Responsibility
Product recalls
Sustainable business practices
Optimizing the Supply Chain Through SCM
Supply Chain Management (SCM)
Supply Chain Planning
Supply Chain Execution
Supply Chain Visibility and Analytics

Functions the Optimize the Supply Network
Developing an SCM Strategy
Trade-offs
Supply Chain Efficiency
Minimizes cost, but increased risk of stock-outs
May sacrifice customer service
Supply Chain Effectiveness
Maximizes likelihood of meeting objectives
Increased costs associated with
Redundancy
Sticking levels
Cross-functionality
Developing an SCM Strategy
Supply Chain Planning (SCP)
SCP involves multiple SCM tools and modules working together to meet business needs and customer demand
SCP Processes
Demand Planning and Forecasting
Based on historical data, build a demand forecast
Distribution Planning
How to move products to distributors, transportation planning
Production Scheduling
Coordinate product/service creation, production plan
Inventory and Safety Stock Planning
Developing inventory estimates, determine optimal inventory levels, sourcing plan

Supply Chain Execution (SCE)
SCE focuses on the efficient and effective flow of materials, information, and financial transactions
SCE Flows
Product Flow
Movement of goods from supplier to production to distribution to consumer
RFID is an important enabling technology
Information Flow
Movement of information through supply chain (e.g., order processing and delivery status updates)
XML is an important enabling technology
Financial Flow
Movement of financial assets through supply chain
Payment schedules, consignment, ownership
Linkages to electronic banking and financial institutions

Financial Flow

Key Technologies for Enhancing SCM
Radio Frequency Identification (RFID)
Replaces bar codes
As low as 10 cents
Extensible Markup Language
XML, much like HTML for Web sites, creates a standard many businesses can use to help facilitate data exchange
Key Technologies for Enhancing SCM: Radio Frequency Identification
Key Technologies for Enhancing SCM: Extensible Markup Language
Managing B2B Financial Transactions
B2B Financial Transactions
B2C often uses e-payments such as PayPal
But B2C still primarily uses payment by check (75%)
Others: purchasing cards, letters of credit, Western union
Unknown suppliers and customers create significant fraud risk
Supply Chain Visibility and Analytics
Supply chain visibility
Product tracking
Anticipating adverse impacts
Weather impacts
Labor negotiations
Supply chain analytics
Monitoring SC performance
Identifying problem spots
Customer Relationship Management
Customer Relationships
Customer Relationship Management (CRM) Benefits
Developing a CRM Strategy
Key Elements of a CRM Strategy
Policies and Business Processes
Reflect a customer-focused culture
Customer Service
Quality, satisfaction, enhanced customer experience
Employee Training
For employees from all areas
Data Collection, Analysis, and Sharing
Track all aspects of the customer experience

Architecture of a CRM System
Operational CRM
Sales Force Automation (SFA)
Supports day-to-day sales force activities
Customer Service and Support (CSS)
Automates service requests, complaints, product returns, and information requests
Enterprise Marketing Management (EMM)
Improves the management of promotional campaigns
Operational CRM: Sales Force Automation
Operational CRM: Customer Service and Support
Customer interaction centers (CIC) support multiple communication channels
Evolved from help desks and call centers
Phone îautomatic call distribution systems, virtual hold technologies
Web îself-service technologies
Facebook
Industry blogs
Face-to-face

Operational CRM: Customer Service and Support
Operational CRM: Enterprise Marketing Management
Analytical CRM
Analyzing customer behavior and perceptions in order to provide the business intelligence necessary to identify new opportunities and to provide superior customer service

Key Analytical Technologies (Chapter 6)
Data mining
Decision support
Other business intelligence technologies
Analytical CRM: Digital Dashboards
Analytical CRM: Online Identities
Social CRM
Customers use Facebook and Twitter to comment on products and services
Monitoring social media conversations helps to understand public perceptions
Analytical CRM applications
Microsoft’ s Social Networking Accelerator
Google Alerts
Dell’ s Social Media Listening Command Center

Collaborative CRM
Systems for providing effective and efficient communication with the customer from the entire organization

Greater Customer Focus
Understanding customer history and current needs
Lower Communication Barriers
Personnel have complete customer information
Personnel use customer-preferred communication methods
Increased Information Integration
Personnel know prior and ongoing communication
Ethical Concerns with CRM
CRM systems may facilitate coercive sales practices
Systems may categorize customers in a way customers take offense to
Personalized communication may become too personal
End of Chapter Content
Managing in the Digital World: Walmart
Walmart is known for cutting costs and prices
Effective use of technology for supply chain
Vendor-managed inventory
Suppliers monitor inventory in Walmart’ s warehouses
Cross-docking: direct transfers from inbound to outbound truck trailers
Powerful CRM capabilities

When Things Go Wrong: Switching Switches îFailure at a Global Scale
Supply chains are increasingly global
Failure to carefully monitor partnerships can lead to expensive product recalls
Example: GM’ s faulty ignition switches took 10 years to resolve
An engineer covered up a mistake by leaving part number unchanged
Led to difficulty identifying faulty switches

Brief Case: The Formula for Success: Demand Media
Demand Media, Inc. focuses on providing answers to common questions
Uses search data and auction data to identify topics with high interest
Demand Media crowdsources solutions as articles and video clips and posts them to its own sites and YouTube
The traffic to view the answers generates advertising revenue
Demand Media has created a very large content base
45 sites with more traffic than ESPN and NBC combined
Now collaborating with Google
Coming Attractions: Saving Lives Through 3D Bioprinting
3D printing is an alternative to cutting and milling materials to create a part
3D printing builds a part up, eliminating waste
3D printing is now very precise and accurate
3D printing now moving into the world of medicine
Researchers in the Netherlands used 3D printing to replace a patient’ s skull
A UK-based company is using 3D printing to print up to 150 prosthetic eyes an hour
3D bioprinting researchers attempting to print complete organs for transplants
Key Players: Salesforce.com
CRM software is becoming key to business success
Critical for most medium to large organizations
Becoming a necessity for many small businesses
Small business often don’ t have the infrastructure to host complete CRM solutions
Salesforce.com hosts a CRM SaaS in an online cloud
The Sales Cloud
The Service Cloud
Chatter
Who’ s Going Mobile: The Power of Mobile CRM
In many organizations, the sales staff is often in the field
Mobile CRM allows staff to use CRM features on the road
The best mobile CRM has all the functionality of desktop CRM
Mobile CRM promotes efficiency and effectiveness, with many benefits
Increased revenue growth and customer renewals
Larger deal size
Increased user adoption and higher quota attainment
Lower sales force turnover
CRM, including mobile CRM, spending is increasing faster than any other application software investment
Ethical Dilemma: CRM: Targeting or Exploiting?
CRM systems allow companies to look closely at customer behavior and send targeted offers to select customers
Benefits include less advertising to uninterested parties
Fine segmentation may allow companies to take advantage of population groups
Some companies also sell data, without user knowledge or consent, at times in violation of their own stated practices
Verizon’ s Relevant Mobile Advertising campaign monitors customers’ Internet browsing habits
Often these practices are legal, but are they ethical?
Industry Analysis: Manufacturing
Computer-Aided Design (CAD)
Facilitates drawing, design, sharing, and collaboration
CAD design prototypes can be printed on 3D printers
This is called fabbing, and speeds up creation of models
3D printing adds successive layers of materials
SCP and ERP are used for inventory planning, job scheduling, and warehouse management

Typical Process For Bioprinting

3D Printing: organs &tissues
Daniel Medeiros
Biomedical Engineering
Problem
2009: 154,324 patients waiting for organs
27,996 patients received them (18%)
8,864 patients died waiting
Approx. 25 people per day
Cost of surgery & follow up procedures in 2012: $300 billion
Tissue Rejection & Immunosuppressants

3D Printing
Sterolithography
Present day:
$700 million industry
$11 million invested in medical applications (1.6%)
Next 10 years:
$8.9 billion industry
$1.9 billion invested in medical applications (21%)
Typical Process for Bioprinting
Design Approaches
Mini-Tissues

Biomimicry

Self-Assembly
Material/Cell Selection
Synthetic Polymers, Natural Polymers, Extracellular Matrix

Differentiated Cells & Stem Cells
Allogenic v.s Autologous

Discussion
Need
Money
Speed/Time
Biocompatibility
Complexity

Utilizing 3D Bioprinting To Develop Organs

The Challenges of the Internet of Nano Things
Sasitharan Balasubramaniam (Sasi)
(sasi.bala@tut.fi)
Nano Communication Centre
Department of Electronics and Communications Engineering
Tampere University of Technology
Outline
Nanotechnology
Nanomachines
Nano Communications
Molecular Communications
Internet of Nano Things (IoNT)
Applications of IoNT
Plans for Horizon2020

Nanotechnology
Concept was first proposed by Richard Feyman in 1959 in his nobel prize acceptance speech
Plenty of room at the bottom
Nanotechnology are devices on the scale of the order of one billionth of a meter(10-9)
Example materials: Graphene, Nanocrystallites, Nanoparticles
Numerous healthcare applications
Improved monitoring of chronic diseases
Accurate drug delivery
Nanorobots that can perform surgery
Other applications include Aeronautics, Environmental Science

Nanomachine to treat cancer
Issue with current chemotherapy is that drugs kill good cells
Aim -deliver drug to targeted areas
Cut the dosage down by hundred -thousand times
Developed at the University of California, Los Angeles (UCLA)
Honeycomb nanostructure that holds the drug particles
Valves releases particles. Numerous approaches:
Chemical agent
Light

DNA Nanorobot
Developed at Wyss Institute
Robotic device developed from DNA
DNA origami -3D shapes created from folding DNA
Two halves connected with a hinge, and shut using DNA latches
The latches can be designed to recognize certain cell proteins and disease markers
Hold molecules with encoded instructions (antibody fragments)
Used on two types of cancer cells (leukemia and lymphoma)
Problems and Challenges
Scale of nanodevices allows us to .
Reach hard to access areas ..
Access vital information at a whole new level (molecular information) ..
Devices of the future will be built from nanomaterials

Limitation -limited functionalities!!

Communication and networking between nanomachines would further advance their capabilities and functionalities

Nano Communications!
Molecular Communication
Sender nanomachines encode information into information molecules (e.g. DNA, proteins, peptides)
Information can be transmitted through diffusion or active transport
Ability to create communication systems and networks using biological components and processes that are found in nature
Interdisciplinary research (nanotechnology, communication technology, biochemistry, molecular biology)
Diffusion-based Molecular Communications
Communication is performed through diffusion of molecules
Information is embedded into the molecules
Ideally this is suited to fluidic medium
Bacteria Communication Nanonetworks (1)
Bacteria can hold genetic information (plasmids)
DTN Bacteria Nanonetworks
Opportunistic multi-hop routing in bacteria nanonetworks using chemotaxis and conjugation.
Each Bacteria is akin to a mobile node.
Smart Organ
Through tissue engineering we can develop various body parts
Tissues -> Organs (skin, bone)
Using nanomaterial scaffolds, we can grow cells on the scaffold into tissue
Utilizing 3D bioprinting to develop organs
Challenge -integration to the existing system within the body
Integrate sensors into the tissue (Smart tissue)
Robert Langer (BBC, October 2013)

Internet of Things
Internet of NANO Things
IoNT Architecture
IoNT Challenges: Context Models
Cross domains of heterogeneous knowledge bases
IoNT Challenges: Service Models
Multitude of nanodevices and micro-gateways
Big data from nanoscale sensors and networks
New distributed service models (lightweight services)
Applications (1): Body Area NanoNetworks (BAN2)
Applications (2): Smart Cities
EU FET Project Plan (1)
Coordinated Support Action (FET OPEN2 – September 2014) Planned submission September 2014 (7 partners including TSSG – WIT, Ireland (coordinator); Koc, Turkey, TUT (Finland)……..
FET Open (FET OPEN1 – September 2014): Internet of Bacteria Things
Collaborator: Prof. Ozgur B. Akan, Koc University
Partners: University of Helsinki (Finland), Tampere University of Technology (Finland), Koc University (Turkey), University of Cambridge (UK), Tyndall Institute (Ireland)
Objective: To realize a simple bacteria nanonetwork that interfaces to the Internet (software services)
Bridge ICT to Molecular Biology World. Linking communication of behaviour of bacteria to the software services in Telecommunications.
Bacteria communication will be conducted through wet lab experiments (Univ. of Helsinki).

EU FET Project Plan (2)
Conclusion
Basics of Nanotechnology
Examples of Nanomachines
Nano Communication
Electro-magnetic Nano Communications
Molecular Communications
Internet of Nano Things
Body Area Nanonetworks
Smart Cities Applications
Plans for Horizon2020